Showing posts with label Brain health. Show all posts
Showing posts with label Brain health. Show all posts

Addiction and Neurotransmitters

What are neurotransmitters?

Neurotransmitters are chemicals that are naturally excreted in the brain, they are acetyl choline, dopamine, endorphins, serotonin, dopamine and GABA (Gamma-Amino-Butyric-Acid).

They function in the transmission of the nerve signals throughout the body. They also function in many processes that our bodies carry out such as sleeping, memory regulation, mood and behavior. They also regulate the body's stimulation and the feeling of pleasure and satisfaction when they are secreted by the brain's reward system.

But, how is addiction related to neurotransmitters?

Neurotransmitters perform all of their functions together through different secretion ratios in the brain. But not all of us have equal amounts of neurotransmitters secreted in our brains, imbalances are so common, for example, nearly 85% of the population have low levels of serotonin secreted in their brains which makes them more tending to get addicted to a substance or a behavior to replace the missing neurotransmitter and feel better.

The imbalances of neurotransmitters cause many problems and balancing those helps a lot to overcome these problems which are: severe headaches, migraine, ADHD, addiction, sleep issues, anxiety, depression, focus and memory problems. But detecting neurotransmitters levels is helpful in rebalancing them in order to treat the situation.

We think that those imbalances of neurotransmitters are mainly due to early deprivation, abuse, trauma, dysfunctional attachment and genetic disorders and on the long term lead to addiction.

Neurotransmitters are classified according to their action in to inhibitory and excitatory neurotransmitters, each type is affected by addictive drugs through a special mechanism. Their normal levels in the brains are crucial for good brain health.

Explained as follows:

Inhibitory neurotransmitters:

They are neurotransmitters that inhibit the stimulation of neurotransmitters, examples of them are: GABA and serotonin.

GABA and serotonin are involved in bringing calmness and pleasure, they are secreted in parts of the brain to prevent excessive stimulation, and the decrease in the level of GABA causes involuntary motor actions including tremors, seizures and anxiety. While decreased amount of serotonin secretion causes depression.

Taking inhibitory drugs as alcohol lead to more and more decrease in the secretion of these neurotransmitters.

Excitatory neurotransmitters:

They include Dopamine which is involved in motivation, emotion, feelings, learning and also pleasure feeling when released by the reward system of the brain.

Dopamine secretion increases after taking addictive drugs like alcohol, cocaine, and other stimulants, but after many successive dosages of the drug, the level of dopamine secreted decreases gradually so the addict doesn't experience the pleasure feeling he's used to, leading to a biologic demand to the addicted drugs to replenish the depleted dopamine leading to the dependence to the drug.

Treatment of addiction:

Up till now all the trials used to reactivate the receptors of different neurotransmitters have failed. And a group of agonists are being used.


https://ezinearticles.com/?Addiction-and-Neurotransmitters&id=9539716

7 Habits That May Actually Change the Brain, According to Science



What does science actually tell us can help our brains? Here's what we know as of now.



The brain is by far our most precious organ–others are good, too, but they all pale in comparison to the mighty brain. Because the brain works so hard around the clock (even while we’re sleeping), it uses an extraordinary amount of energy, and requires a certain amount of nutritional support to keep it going. It’s high-maintenance, in other words. But there may be misconceptions about what keeps a brain healthy–for instance, there’s little evidence that omega-3 supplements or green smoothies would do anything above and beyond generally good nutrition. So what does science actually tell us can help our brains? Here’s what we know as of now.

Exercise

Physical activity is pretty clearly linked to brain health and cognitive function. People who exercise appear to have greater brain volume, better thinking and memory skills, and even reduced risk of dementia. A recent study in the journal Neurology found that older people who vigorously exercise have cognitive test scores that place them at the equivalent of 10 years younger. It’s not totally clear why this is, but it’s likely due to the increased blood flow to the brain that comes from physical activity. Exercise is also thought to help generate new neurons in the hippocampus, the brain area where learning and memory “live,” and which is known to lose volume with age, depression and Alzheimer’s disease. The one stark exception to the exercise rule is impact sports like football, which has been shown again and again to be linked to brain damage and dementia, since even low-level impacts can accrue over time. The same is true for soccer headers.
Starting an exercise routine earlier in life is likely the best way to go, and the effects more pronounced the younger one begins. More research will be needed, but in the meantime, enough research has shown exercise to be beneficial to the brain that it’s pretty hard not to at least acknowledge it (even if we don’t do it as much as we should).

Meditation

This connection is fascinating, because although there are thousands of years of anecdotal evidence that meditation can help a person psychologically, and perhaps neurologically, the scientific evidence for meditation’s effects on the brain has really just exploded in the last five or 10 years. Meditation has been linked to increased brain volume in certain areas of the cerebral cortex, along with less volume in the brain’s amygdala, which controls fear and anxiety. It’s also been linked to reduced activity in the brain’s default mode network (DMN), which is active when our minds are wandering about from thought to thought, which are typically negative and distressing. Meditation also seems to lead to changes to the white matter tracks connecting different regions of the brain, and to improved attention and concentration.

Sleep

The brain does an awful lot of work while we’re sleeping–in fact, it really never sleeps. It’s always consolidating memories and pruning unnecessary connections. Sleep deprivation, and just a little of it, takes a toll on our cognitive health. It’s linked to worse cognitive function, and poorer attention, learning and creative thinking. The more sleep debt you accrue, the longer it takes to undo it. Sleeping for about seven hours per night seems to be a good target to aim for.
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How to REALLY Boost Your Brain Health



1. Exercise
Exercise encourages your brain to work at optimum capacity by causing nerve cells to multiply, strengthening their interconnections and protecting them from damage. During exercise nerve cells release proteins known as neurotrophic factors. One in particular, called brain-derived neurotrophic factor (BDNF), triggers numerous other chemicals that promote neural health, and directly benefits cognitive functions, including learning. Further, exercise provides protective effects to your brain through:
- The production of nerve-protecting compounds
- Greater blood flow to your brain
- Improved development and survival of neurons
- Decreased risk of cardiovascular diseases such as stroke
A 2010 study on primates published in Neurosciencei also revealed that regular exercise not only improved blood flow to the brain, but also helped the monkeys learn new tasks twice as quickly as non-exercising monkeys, a benefit the researchers believe would hold true for people as well.
Still more research has shown that exercise boosts mitochondria, organelles that produce energy within every cell of your body, which suggests exercise may help your brain work faster and more efficiently.
2. Animal-Based Omega-3 Fats
Docosahexaenoic acid, or DHA, an omega-3 fat, is an essential structural component of both your brain and retina. Approximately 60 percent of your brain is composed of fats—25 percent of which is DHA. DHA is also an essential structural ingredient of breast milk, which is believed to be a major reason why breastfed babies consistently score higher on IQ tests than formula-fed babies.
Omega-3 fats such as DHA are considered essential because your body cannot produce it, and must get it from your daily diet. DHA-rich foods include fish, liver, and brain—all of which are no longer consumed in great amounts by most Americans.
DHA is found in high levels in your neurons — the cells of your central nervous system, where it provides structural support. When your omega-3 intake is inadequate, your nerve cells become stiff and more prone to inflammation as the missing omega-3 fats are substituted with cholesterol and omega-6 instead. Once your nerve cells become rigid and inflamed, proper neurotransmission from cell to cell and within cells become compromised.
The influence of omega-3 fat on physical and mental health has been the subject of intense research over the last four decades, and there’s compelling evidence that animal-based omega-3 fats can help reduce the symptoms of a variety of psychiatric illnesses and degenerative brain disorders. For example, low DHA levels have been linked to memory loss and Alzheimer’s disease.
Even more exciting is research showing that degenerative conditions can not only be prevented but also potentially reversed. For example, in one study, 485 elderly volunteers suffering from memory deficits saw significant improvement after taking 900 mg of DHA per day for 24 weeks, compared with controls.
Another study found significant improvement in verbal fluency scores after taking 800 mg of DHA per day for four months compared with placebo. Furthermore, memory and rate of learning were significantly improved when DHA was combined with 12 mg of lutein per day.
Interestingly, research suggests that the unsaturated fatty acid composition of normal brain tissue is age-specific, which could imply that the older you get, the greater your need for animal-based omega-3 fat to prevent mental decline and brain degeneration.
To compensate for our inherently low omega-3 diet, a high quality animal-based omega-3 supplement is something that I recommend for virtually everyone, especially if you’re pregnant. I prefer krill oil compared to all other animal-based omega-3′s, because while the metabolic effects of krill oil and fish oil are “essentially similar,” krill oil is as effective as fish oil despite the fact that it contains less EPA and DHA.v This is because krill oil is absorbed up to 10-15 times as well as fish oil, due to its molecular composition, and is less prone to oxidation (rancidity) because it is naturally complexed with the potent fat-soluble antioxidant astaxanthin.
3. Sleep


Sleep is not only essential for regenerating your physical body, but it is imperative for reaching new mental insights and being able to see new creative solutions to old problems. Sleep removes the blinders and helps “reset” your brain to look at problems from a different perspective, which is crucial to creativity.
Research from Harvard indicates that people are 33 percent more likely to infer connections among distantly related ideas after sleeping, but few realize that their performance has actually improved. Sleep is also known to enhance your memories and help you “practice” and improve your performance of challenging skills. In fact, a single night of sleeping only four to six hours can impact your ability to think clearly the next day.
The process of growth, known as plasticity, is believed to underlie the brain’s capacity to control behavior, including learning and memory. Plasticity occurs when neurons are stimulated by events, or information, from the environment. However, sleep and sleep loss modify the expression of several genes and gene products that may be important for synaptic plasticity. Furthermore, certain forms of long-term potentiation, a neural process associated with the laying down of learning and memory, can be elicited in sleep, suggesting synaptic connections are strengthened while you slumber.
As you might suspect, this holds true for infants too, and research shows that naps can give a boost to babies’ brainpower. Specifically, infants who slept in between learning and testing sessions had a better ability to recognize patterns in new information, which signals an important change in memory that plays an essential role in cognitive development. Even among adults, a mid-day nap was found to dramatically boost and restore brainpower.
4. Coconut Oil
One of the primary fuels your brain needs is glucose, which is converted into energy. Your brain actually manufactures its own insulin to convert glucose in your bloodstream into the food it needs to survive.
If your brain’s production of insulin decreases, your brain literally begins to starve, as it’s deprived of the glucose-converted energy it needs to function normally. This is what happens to Alzheimer’s patients — portions of their brain start to atrophy, or starve, leading to impaired functioning and eventual loss of memory, speech, movement and personality.
In effect, your brain can begin to atrophy from starvation if it becomes insulin resistant and loses its ability to convert glucose into energy. Fortunately, your brain is able to run on more than one type of energy supply, and this is where coconut oil enters the picture.
There’s another substance that can feed your brain and prevent brain atrophy. It may even restore and renewneuron and nerve function in your brain after damage has set in.
The substance in question is called ketone bodies or ketoacids. Ketones are what your body produces when it converts fat (as opposed to glucose) into energy, and a primary source of ketone bodies are the medium-chain triglycerides (MCT) found in coconut oil! Coconut oil contains about 66 percent MCTs. Therapeutic levels of MCTs have been studied at 20 grams per day. According to research by Dr. Mary Newport, just over two tablespoons of coconut oil (about 35 ml or 7 level teaspoons) would supply you with the equivalent of 20 grams of MCT, which is indicated as either a preventative measure against degenerative neurological diseases, or as a treatment for an already established case.
Everyone tolerates coconut oil differently, so you may have to start slowly and build up to these therapeutic levels. My recommendation is to start with one teaspoon, taken with food in the mornings. Gradually add more coconut oil every few days until you can tolerate four tablespoons. Coconut oil is best taken with food, to avoid upsetting your stomach.
5. Vitamin D
Activated vitamin D receptors increase nerve growth in your brain, and researchers have also located metabolic pathways for vitamin D in the hippocampus and cerebellum of the brain, areas that are involved in planning, processing of information, and the formation of new memories.
The National Institutes of Mental Health recently concluded that it is vital that the mother get enough vitamin D while pregnant in order for the baby’s brain to develop properly. The child must also get enough vitamin D after birth for “normal” brain functioning. In older adults, too, research has shown that low vitamin D levels are associated with poorer brain function, and increasing levels may help keep older adults mentally fit.
Appropriate sun exposure would take care of these issues, as the sun is irreplaceable when it comes to the body’s ability to produce adequate amounts of vitamin D.
Appropriate sun exposure is all it takes to keep your levels where they need to be for healthy brain function. If this is not an option, a safe tanning bed is the next best alternative, followed by a vitamin D3 supplement. It now appears as though most adults need about 8,000 IU’s of vitamin D a day in order to get their serum levels above 40 ng/ml, which is the lowest they should be. Ideally, your serum levels should be between 50-70 ng/ml, and up to 100 ng/ml to treat cancer and heart disease. However, it’s important to realize that there’s no magic dosage when it comes to vitamin D. What’s important is your serum level, so you need to get your vitamin D levels tested to make sure you’re staying within the optimal and therapeutic ranges as indicated below.
6. Optimize Your Gut Flora
Your gut is your “second brain,” and your gut bacteria transmits information to your brain via the vagus nerve, the tenth cranial nerve that runs from your brain stem into your enteric nervous system (the nervous system of your gastrointestinal tract). There is a close connection between abnormal gut flora and abnormal brain development, and just as you have neurons in your brain, you also have neurons in your gut — including neurons that produce neurotransmitters like serotonin, which is also found in your brain and is linked to mood.
Quite simply, your gut health can impact your brain function, psyche, and behavior, as they are interconnected and interdependent in a number of different ways.
Your gut bacteria are an active and integrated part of your body, and as such are heavily dependent on your diet and vulnerable to your lifestyle. If you consume a lot of processed foods and sweetened drinks, for instance, your gut bacteria are likely going to be severely compromised because processed foods in general will destroy healthy microflora and sugars of all kinds feed bad bacteria and yeast. Limiting sugar and processed foods, while eating traditionally fermented foods (rich in naturally occurring good bacteria), taking a probiotic supplement and breastfeeding your baby are among the best ways to optimize gut flora and subsequently support brain health.
7. Vitamin B12
Vitamin B12, or rather a lack thereof, has been called the “canary in the coalmine” for your future brain health, and recent research has bolstered the importance of this vitamin in keeping your mind sharp as you age. According to the latest research, people with high levels of markers for vitamin B12 deficiency were more likely to score lower on cognitive tests, as well as have a smaller total brain volume,ix which suggests a lack of the vitamin may contribute to brain shrinkage.
Mental fogginess and problems with memory are two of the top warning signs that you have vitamin B12 deficiency, and this is indicative of its importance for your brain health.
In addition, a Finnish study found that people who consume foods rich in B12 may reduce their risk of Alzheimer’s in their later years.x For each unit increase in the marker of vitamin B12 (holotranscobalamin) the risk of developing Alzheimer’s was reduced by 2 percent. Research also shows that supplementing with B vitamins, including B12, helps to slow brain atrophy in elderly people with mild cognitive impairment (brain atrophy is a well-established characteristic of Alzheimer’s disease).
Vitamin B12 deficiency is widespread and many have trouble absorbing this nutrient properly from food sources. Blood tests for vitamin B12 are not always a reliable indicator of B12 status, so watching for symptoms of deficiency and increasing your dietary and supplemental intake is a practical alternative to blood testing.
B12 is available in its natural form only in animal food sources. These include seafood, beef, chicken, pork, milk, and eggs. If you don’t consume enough of these animal products (and I don’t recommend consuming seafood unless you know it is from a pure water source) to get an adequate supply of B12, or if your body’s ability to absorb the vitamin from food is compromised, vitamin B12 supplementation is completely non-toxic and inexpensive, especially when compared to the cost of laboratory testing. I recommend an under-the-tongue fine mist spray, as this technology helps you absorb the vitamin into the fine capillaries under your tongue.
8. Listen to Music

It’s long been theorized that listening to music may boost your brainpower; you’ve probably heard of this with the “Mozart Effect,” which suggests listening to classical music can make you smarter. Indeed, research has shown that listening to music while exercising boosted cognitive levels and verbal fluency skills in people diagnosed with coronary artery disease (coronary artery disease has been linked to a decline in cognitive abilities). In this study, signs of improvement in the verbal fluency areas more than doubled after listening to music compared to that of the non-music session.
Listening to music has also been associated with enhanced cognitive functioning and improved mental focus among healthy adults, so take advantage of this simple pleasure whenever you can.
9. Challenge Your Mind
One of the simplest methods to boost your brain function is to keep on learning. The size and structure of neurons and the connections between them actually change as you learn. This can take on many forms above and beyond book learning to include activities like travelling, learning to play a musical instrument or speak a foreign language, or participating in social and community activities.
Another important method? Brain aerobics. As with learning, challenging your brain with mind-training exercises can keep your brain fit as you age. This can be something as simple as thinking of famous people whose first names begin with the letter A, doing crossword puzzles or playing board games that get you thinking. Research has even shown that surfing the Web activates regions in your brain related to decision-making and complex reasoning. So unlike passively watching TV, using the Internet is an engaging task that may actually help to improve your brainpower.

5 Steps to Better Brain Health



The number of people who'll develop dementia in the next 20 years is expected to substantially increase. It’s no surprise then that millions of research dollars are being earmarked for unlocking the combination for sustained brain health—either to prevent dementia or, at least, slow it down. Much of this research targets pharmaceutical interventions, but there is increasing data substantiating the importance of lifestyle factors in sustaining brain health as well.
Let’s examine five that appear to influence brain health:
  1. Nutrition
    No surprises here. In general, the types of foods and nutritional habits that reduce heart disease and diabetes appear to benefit the brain as well. A diet low in saturated fat and sugar promotes better blood circulation within the brain, whereas saturated foods clog the arteries that feed the brain. Several studies have found a protective effect with fish consumption, particularly those with higher omega-3 percentages, such as salmon and tuna. Nuts and dark-colored vegetables, berries, as well as the Mediterranean diet, which emphasizes plant-based foods including whole grains, legumes and nuts, plus a splash of olive oil, are also proven to help brain function. More recently, fish oil capsules in a recent study have been found to preserve cognitive function and brain volume. Further, deficient  levels of Vitamin D have been found to significantly increase the risk of Alzheimer's disease.
  2. Health
    As you might expect, high blood pressure and being overweight significantly increase the odds of dementia later in life. Weight gain can significantly elevate blood pressure, and high blood pressure increases the risk of strokes. Even small strokes (microinfarcts), which are often undiagnosed, may set up the brain for dementia. For example, studies have found that individuals who had high amounts of microinfarcts also had the lowest cognitive scores.
  3. Brain Games
    Since the brain builds neural networks by learning new material, quite a bit of attention has focused on creating games that will build up the brain’s “muscle.” Crossword and maths puzzles are frequently mentioned in this category. More recently, private companies have developed computer games for the purpose of stimulating different brain functions, particularly concentration. There is some data to support that this can make a difference, but the majority of this research has been conducted by the actual game manufacturers. Unfortunately, it appears that any gains achieved in these games do not typically extend beyond the specific game itself, let alone to daily life.
  4. Stretching the Comfort Zone
    Muscles grow by being challenged and feeling uncomfortable. It is quite likely that the brain grows in the same way and, like a muscle, it too needs to be challenged in ways that make it somewhat uncomfortable. In particular, it might be that learning for the sake of learning is not always enough. Perhaps emotional challenges might offer a more substantive impact. For example, individuals who are engaged with others in problem solving show some protective effect against dementia. Perhaps this is due to the brain being stimulated in both the cognitive problem solving and the emotional regions of the brain. Conversely, individuals who are depressed and isolated are at a higher risk for dementia. Overall, it is possible that the activities which are both a cognitive and an emotional challenge deliver the greatest benefit. Examples of these types of challenges include learning and conversing with others in a new language, taking up a musical instrument and performing with other musicians in front of live audiences, actively volunteering and participating in new causes that you feel passionate about, or even taking up public speaking–particularly if you have been fearful of doing so in the past.
  5. Meditation and Hypnosis
    Both hypnosis and meditation have been proven to spark changes in the brain. They are capable of influencing vascular blood flow, electrical activity and stimulating specific regions of the brain. Furthermore, both approaches can influence the magnitude of inflammation in the body. These methods are excellent tools for controlling the stress and the fear response, which are directly connected to the inflammatory response. What makes this particularly important is that the inflammatory process is associated with dementia. Although it has not been proven to cause dementia, there is strong evidence that it influences the progression of the dementia process. Additionally, inflammation is strongly linked with actually shrinking the hippocampus, the brain’s memory centre, which is significant because an atrophied hippocampus is often found in Alzheimer’s. For many, the idea of taking time out for meditation and hypnosis might seem formidable. Fortunately, there are studies that reveal how even short interludes of hypnosis and meditation can make a substantive difference—even something as simple as listening to a guided recording at night.
The brain is a muscle, and like any other muscle, it needs to be kept in shape through nutrition, mind-body techniques, and interactive problem solving. Remember: A stimulated brain is a happy brain.